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Substances: Tetrahydrogestrinone (THG)

Tetrahydrogestrinone (THG) is a designer (or structurally modified) anabolic androgenic steroid that is prohibited in sport. THG was developed via manipulation of another prohibited substance to illicitly enhance elite sports performance.

Athletes may be tempted to use anabolic steroids as they can improve the body’s capacity to train and compete at the highest level by reducing fatigue associated with training and the time required to recover after physical exertion.

Steroid use also promotes the development of muscle and tissue in the body, which can be associated with an increase in strength and power and may decrease recovery time following injury.

Detection

In mid-2003 the International Olympic Committee / World Anti-Doping Agency accredited laboratory in Los Angeles was provided with a sample of a substance that has enabled the structure of THG to be determined and a detection methodology to be developed.

The protocol for THG detection has been communicated to all IOC / WADA accredited laboratories throughout the world and is now incorporated into regular sample analysis globally.

Side Effects

Structural modification of a substance may alter the intended physiological interactions it has with other substances and receptors within the body. For this reason the greatest risk associated with using designer steroids which have not undergone rigorous clinical testing and validation is the onset of unknown side effects that may result from adverse physiological interactions.

Generally side effects of anabolic steroid use may include jaundice and liver damage, acne, heart problems, euphoria, improved self-esteem, mood swings, depression, paranoia and aggression.

Effects specific to males may include the development of breast tissue, infertility and baldness.

Effects specific to females may include an increase in facial and body hair, menstrual problems, and permanent deepening of the voice, foetal damage and clitoral enlargement.

Status in sport

THG is prohibited both in and out of competition under the World Anti-Doping Code 2007 Prohibited List (effective from 01/01/07).

 

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